San Francisco 49ers

Christian McCaffrey (rest/Achilles) is not practicing for the 49ers on Wednesday. (Source: Nick Wagoner on Twitter)

Fantasy Impact: To no surprise, McCaffrey will be a non-participant to start the week. The team is giving him a rest day at the start of the week to manage the Achilles injury that left him sidelined for the start of the season, but he's expected to be fully good to go for Week 12's matchup against the Green Bay Packers.

George Kittle (hamstring) will be limited at San Francisco's practice on Wednesday. (Source: Nick Wagoner on Twitter)

Fantasy Impact: Kittle missed Week 11's game due to a hamstring injury, but he is set to return to practice in a limited fashion on Wednesday. That bodes well for his Week 12 availability, assuming all goes well at practice throughout the week. Fantasy managers should not hesitate to start him if he's active against the Packers on Sunday.

Trent Williams (ankle) will be sidelined from San Francisco's practice on Wednesday. (Source: Nick Wagoner on Twitter)

Fantasy Impact: The 49ers will not have Williams at practice on Wednesday. He's managing an ankle injury right now, but he was able to play through it in Week 11, so it doesn't seem to be a serious issue. He should play in Week 12 barring any setbacks, which is great news for San Francisco's offense as a whole.

Nick Bosa (hip/oblique) will be a non-participant in San Francisco's practice on Wednesday. (Source: Nick Wagoner on Twitter)

Fantasy Impact: Bosa will miss San Francisco's first practice of the week on Wednesday due to a hip/oblique injury. His status for Week 12 is currently unclear and will likely depend on his practice participation on Thursday and Friday. San Francisco's defense is facing a big matchup against Green Bay's offense in Week 12, so they will benefit greatly if the star defensive end is available to play.

Brock Purdy (shoulder) will be limited in San Francisco's practice on Wednesday. (Source: Nick Wagoner on Twitter)

Fantasy Impact: Purdy is considered day-to-day due to a shoulder injury right now, and he will be limited in San Francisco's practice on Wednesday as a result. It looks like he's going to be available to play in Week 12, but we won't know for sure until later in the week.

The 49ers D/ST allowed 20 points on 289 total yards with four sacks and an interception on Sunday.

Fantasy Impact: San Francisco was able to get Geno Smith in the first half. After Nick Bosa left early, they struggled including a game-winning drive at the end. They'll take on the Packers on the road next week.

Jake Moody made his lone field goal (33) and 2-of-2 extra point attempts on Sunday.

Fantasy Impact: Moody made all three of his attempts. The 49ers offense as of late limits his upside a bit for fantasy managers.

Eric Saubert caught his lone target for seven yards in the 49ers 20-17 loss against the Seahawks.

Fantasy Impact: Saubert saw some more snaps with George Kittle sidelined. He remains off the fantasy radar.

Ricky Pearsall did not catch either of his two targets in the 49ers 20-17 loss against the Seahawks.

Fantasy Impact: After hauling in his first career touchdown last week, Pearsall went without a catch on Sunday despite the absence of George Kittle. He'll be a WR4 moving forward with WR3 upside.

Deebo Samuel Sr. caught 4-of-7 targets for 22 yards in the 49ers 20-17 loss against the Seahawks.

Fantasy Impact: It was a very quiet day for Samuel as Jauan Jennings was the clear No. 1 wide receiver for the 49ers. Samuel will be a WR2 play next week.

Jauan Jennings caught 10-of-11 targets for 91 yards and a touchdown in the 49ers 20-17 loss against the Seahawks.

Fantasy Impact: Jennings seemed to get open as a safety blanket for Brock Purdy all afternoon with George Kittle sidelined. He could be a WR2 play next week, especially if Kittle misses another game.

Jordan Mason ran for 13 yards on two carries in the 49ers 20-17 loss against the Seahawks.

Fantasy Impact: Mason has seen three carries in two games since the return of Christian McCaffrey. He remains the backup moving forward.

49ers GM John Lynch said "we're getting closer" to having Dre Greenlaw coming back. (Source: Matt Barrows on Twitter)

Fantasy Impact: Lynch added that once Greenlaw's practice window opens, he will use a good chunk of that window. He is likely still at least a few weeks away from officially returning for San Francisco.

Yetur Gross-Matos is on track to return on Sunday against the Seahawks. (Source: David Lombardi on Twitter)

Fantasy Impact: It's "looking pretty good" according to 49ers GM John Lynch. Gross-Matos has been sidelined for the past month after undergoing surgery on his knee.

The 49ers signed Pat O'Donnell to their practice squad.

Fantasy Impact: San Francisco punter Mitch Wishnowsky suffered a back injury last week. If he can't go on Sunday, O'Donnell will be activated to start.

Isaac Guerendo did not record a yard on one carry in the 49ers 23-20 win over the Buccaneers.

Fantasy Impact: Guerendo and Jordan Mason both saw just one carry each with the return of Christian McCaffrey. They're both stashes now with the return of McCaffrey.

The 49ers signed LB Jalen Graham to their practice squad. (Source: San Francisco 49ers on Twitter)

Fantasy Impact: Graham will add depth to the linebacker room for San Francisco. The 49ers released OL Dieter Eiselen from the practice squad as the corresponding move.

Anders Carlson made all three of his field goals while adding three extra points in a 30-24 win over Dallas in Week 8.

Fantasy Impact: Carlson was perfect on the evening, making field goals from 50, 44, and 41 yards out. The veteran kicker has done an admirable job filling in for the injured Jake Moody (ankle) over the past two games, going 5-for-5 on field goals. The 49ers will be on bye in Week 9, giving Moody an extra week to get healthy.

George Odum has been listed as questionable for Sunday's game against the Cowboys. (Source: Josh Dubow on Twitter)

Fantasy Impact: Odum was limited at practice on Thursday and Friday. He should be on the favorable side of questionable heading into Sunday.

Deommodore Lenoir has been listed as questionable for Sunday's game against the Cowboys. (Source: Josh Dubow on Twitter)

Fantasy Impact: Lenoir was limited to close the week on Friday. He should be good to go for Sunday's game barring any setbacks with his illness.