Brandon Aiyuk

Brandon Aiyuk has been placed on the reserve/left squad list by the 49ers.

Fantasy Impact

This move by the 49ers ultimately ends any hope of Aiyuk making a late-season return. The two sides have been at odds for a while now, and the team has simply decided to move on. Aiyuk will have the chance to sign with a new team during the upcoming offseason.

49ers GM John Lynch said he’s “hopeful” WR Brandon Aiyuk will play for the team this season.

Fantasy Impact

Lynch couldn't fully commit to Aiyuk playing this season, but he said he is hopeful. He will not have his practice window opened this week.

The 49ers will not open the practice window for Brandon Aiyuk this week.

Fantasy Impact

Aiyuk had 2026 guarantees voided on his contract. It is seeming more unlikely that he plays this week.

Brandon Aiyuk will have his 2026 guarantees voided by the 49ers because he did not hold up his end of his contract. The move puts him on track to be released at the end of the season.

Fantasy Impact

This is massive news for the 49ers, especially after being just over a year removed from signing a 4-year, $120 million deal with Aiyuk in 2024 after a messy holdout. The talented receiver should have a market in 2026, but one has to wonder if he will get anything close to what he would have gotten on his deal with the Niners. San Francisco will look to bolster their receiving room through free agency and the draft, as well as potentially re-signing current vets like Jauan Jennings to new deals.

49ers coach Kyle Shanahan said the team will not open the practice window for Brandon Aiyuk this week.

Fantasy Impact

Aiyuk remains week-to-week. He remains hopeful to return at some point by the end of the season.