| Week 1 | New York Jets vs. San Francisco 49ers | Monday, September 9th, 2024 at 8:15pm ET |
| Week 2 | San Francisco 49ers vs. Minnesota Vikings | Sunday, September 15th, 2024 at 1:00pm ET |
| Week 3 | San Francisco 49ers vs. Los Angeles Rams | Sunday, September 22nd, 2024 at 4:25pm ET |
| Week 4 | New England Patriots vs. San Francisco 49ers | Sunday, September 29th, 2024 at 4:05pm ET |
| Week 5 | Arizona Cardinals vs. San Francisco 49ers | Sunday, October 6th, 2024 at 4:05pm ET |
| Week 6 | San Francisco 49ers vs. Seattle Seahawks | Thursday, October 10th, 2024 at 8:15pm ET |
| Week 7 | Kansas City Chiefs vs. San Francisco 49ers | Sunday, October 20th, 2024 at 4:25pm ET |
| Week 8 | Dallas Cowboys vs. San Francisco 49ers | Sunday, October 27th, 2024 at 8:20pm ET |
| Week 9 | Bye Week | |
| Week 10 | San Francisco 49ers vs. Tampa Bay Buccaneers | Sunday, November 10th, 2024 at 1:00pm ET |
| Week 11 | Seattle Seahawks vs. San Francisco 49ers | Sunday, November 17th, 2024 at 4:05pm ET |
| Week 12 | San Francisco 49ers vs. Green Bay Packers | Sunday, November 24th, 2024 at 4:25pm ET |
| Week 13 | San Francisco 49ers vs. Buffalo Bills | Sunday, December 1st, 2024 at 8:20pm ET |
| Week 14 | Chicago Bears vs. San Francisco 49ers | Sunday, December 8th, 2024 at 4:25pm ET |
| Week 15 | Los Angeles Rams vs. San Francisco 49ers | Thursday, December 12th, 2024 at 8:15pm ET |
| Week 16 | San Francisco 49ers vs. Miami Dolphins | Sunday, December 22nd, 2024 at 4:25pm ET |
| Week 17 | Detroit Lions vs. San Francisco 49ers | Monday, December 30th, 2024 at 8:15pm ET |
| Week 18 | San Francisco 49ers vs. Arizona Cardinals | Sunday, January 5th, 2025 at 1:00pm ET |
