Buffalo Sabres
Atlantic Division
| Date (ET) | Opponent |
|---|---|
| Thu Oct 9, 7:00pm | vs. New York Rangers |
| Sat Oct 11, 7:00pm | at. Boston Bruins |
| Mon Oct 13, 12:30pm | vs. Colorado Avalanche |
| Wed Oct 15, 7:00pm | vs. Ottawa Senators |
| Sat Oct 18, 1:00pm | vs. Florida Panthers |
| Mon Oct 20, 7:30pm | at. Montreal Canadiens |
| Wed Oct 22, 7:30pm | vs. Detroit Red Wings |
| Fri Oct 24, 7:00pm | vs. Toronto Maple Leafs |
| Sat Oct 25, 5:00pm | at. Toronto Maple Leafs |
| Tue Oct 28, 6:45pm | vs. Columbus Blue Jackets |
| Thu Oct 30, 7:00pm | at. Boston Bruins |
| Sat Nov 1, 7:00pm | vs. Washington Capitals |
| Tue Nov 4, 7:00pm | vs. Utah Mammoth |
| Thu Nov 6, 7:00pm | vs. St. Louis Blues |
| Sat Nov 8, 7:00pm | at. Carolina Hurricanes |
| Wed Nov 12, 9:00pm | at. Utah Mammoth |
| Thu Nov 13, 9:00pm | at. Colorado Avalanche |
| Sat Nov 15, 7:00pm | at. Detroit Red Wings |
| Mon Nov 17, 7:00pm | vs. Edmonton Oilers |
| Wed Nov 19, 7:30pm | vs. Calgary Flames |
| Fri Nov 21, 7:00pm | vs. Chicago Blackhawks |
| Sun Nov 23, 1:00pm | vs. Carolina Hurricanes |
| Wed Nov 26, 7:00pm | at. Pittsburgh Penguins |
| Fri Nov 28, 4:00pm | vs. New Jersey Devils |
| Sat Nov 29, 8:00pm | at. Minnesota Wild |
| Mon Dec 1, 7:30pm | vs. Winnipeg Jets |
| Wed Dec 3, 7:30pm | at. Philadelphia Flyers |
| Fri Dec 5, 7:00pm | at. Winnipeg Jets |
| Mon Dec 8, 9:00pm | at. Calgary Flames |
| Tue Dec 9, 9:00pm | at. Edmonton Oilers |
| Thu Dec 11, 10:00pm | at. Vancouver Canucks |
| Sun Dec 14, 8:00pm | at. Seattle Kraken |
| Thu Dec 18, 7:30pm | vs. Philadelphia Flyers |
| Sat Dec 20, 5:00pm | vs. New York Islanders |
| Sun Dec 21, 7:00pm | at. New Jersey Devils |
| Tue Dec 23, 7:00pm | at. Ottawa Senators |
| Sat Dec 27, 7:00pm | vs. Boston Bruins |
| Mon Dec 29, 8:00pm | at. St. Louis Blues |
| Wed Dec 31, 8:00pm | at. Dallas Stars |
| Sat Jan 3, 3:00pm | at. Columbus Blue Jackets |
| Tue Jan 6, 7:00pm | vs. Vancouver Canucks |
| Thu Jan 8, 7:00pm | at. New York Rangers |
| Date (ET) | Opponent | |
|---|---|---|
| Sat Jan 10, 7:00pm | vs. Anaheim Ducks | |
| Mon Jan 12, 7:00pm | vs. Florida Panthers | |
| Wed Jan 14, 7:30pm | vs. Philadelphia Flyers | |
| Thu Jan 15, 7:00pm | vs. Montreal Canadiens | |
| Sat Jan 17, 12:30pm | vs. Minnesota Wild | |
| Mon Jan 19, 1:30pm | at. Carolina Hurricanes | |
| Tue Jan 20, 8:00pm | at. Nashville Predators | |
| Thu Jan 22, 7:00pm | at. Montreal Canadiens | |
| Sat Jan 24, 1:00pm | at. New York Islanders | |
| Tue Jan 27, 7:00pm | at. Toronto Maple Leafs | |
| Thu Jan 29, 7:00pm | vs. Los Angeles Kings | |
| Sat Jan 31, 7:00pm | vs. Montreal Canadiens | |
| Mon Feb 2, 7:00pm | at. Florida Panthers | |
| Tue Feb 3, 7:30pm | at. Tampa Bay Lightning | |
| Thu Feb 5, 7:00pm | vs. Pittsburgh Penguins | |
| Thu Feb 12, 8:00pm | NHL All-Star Game | |
| Wed Feb 25, 7:00pm | at. New Jersey Devils | |
| Fri Feb 27, 7:00pm | at. Florida Panthers | |
| Sat Feb 28, 7:00pm | at. Tampa Bay Lightning | |
| Tue Mar 3, 7:00pm | vs. Vegas Golden Knights | |
| Thu Mar 5, 7:00pm | at. Pittsburgh Penguins | |
| Sat Mar 7, 5:30pm | vs. Nashville Predators | |
| Sun Mar 8, 6:00pm | vs. Tampa Bay Lightning | |
| Tue Mar 10, 7:00pm | vs. San Jose Sharks | |
| Thu Mar 12, 7:00pm | vs. Washington Capitals | |
| Sat Mar 14, 7:00pm | vs. Toronto Maple Leafs | |
| Tue Mar 17, 10:00pm | at. Vegas Golden Knights | |
| Thu Mar 19, 10:00pm | at. San Jose Sharks | |
| Sat Mar 21, 4:00pm | at. Los Angeles Kings | |
| Sun Mar 22, 8:00pm | at. Anaheim Ducks | |
| Wed Mar 25, 7:00pm | vs. Boston Bruins | |
| Fri Mar 27, 7:00pm | vs. Detroit Red Wings | |
| Sat Mar 28, 5:30pm | vs. Seattle Kraken | |
| Tue Mar 31, 7:00pm | vs. New York Islanders | |
| Thu Apr 2, 7:00pm | at. Ottawa Senators | |
| Sat Apr 4, 7:00pm | at. Washington Capitals | |
| Mon Apr 6, 7:00pm | vs. Tampa Bay Lightning | |
| Wed Apr 8, 7:00pm | at. New York Rangers | |
| Thu Apr 9, 7:00pm | vs. Columbus Blue Jackets | |
| Mon Apr 13, 8:30pm | at. Chicago Blackhawks | |
| Wed Apr 15, 7:00pm | vs. Dallas Stars | |
