| Week 1 | Houston Texans vs. Indianapolis Colts | Sunday, September 8th, 2024 at 1:00pm ET |
| Week 2 | Chicago Bears vs. Houston Texans | Sunday, September 15th, 2024 at 8:20pm ET |
| Week 3 | Houston Texans vs. Minnesota Vikings | Sunday, September 22nd, 2024 at 1:00pm ET |
| Week 4 | Jacksonville Jaguars vs. Houston Texans | Sunday, September 29th, 2024 at 1:00pm ET |
| Week 5 | Buffalo Bills vs. Houston Texans | Sunday, October 6th, 2024 at 1:00pm ET |
| Week 6 | Houston Texans vs. New England Patriots | Sunday, October 13th, 2024 at 1:00pm ET |
| Week 7 | Houston Texans vs. Green Bay Packers | Sunday, October 20th, 2024 at 1:00pm ET |
| Week 8 | Indianapolis Colts vs. Houston Texans | Sunday, October 27th, 2024 at 1:00pm ET |
| Week 9 | Houston Texans vs. New York Jets | Thursday, October 31st, 2024 at 8:15pm ET |
| Week 10 | Detroit Lions vs. Houston Texans | Sunday, November 10th, 2024 at 8:20pm ET |
| Week 11 | Houston Texans vs. Dallas Cowboys | Monday, November 18th, 2024 at 8:15pm ET |
| Week 12 | Tennessee Titans vs. Houston Texans | Sunday, November 24th, 2024 at 1:00pm ET |
| Week 13 | Houston Texans vs. Jacksonville Jaguars | Sunday, December 1st, 2024 at 1:00pm ET |
| Week 14 | Bye Week | |
| Week 15 | Miami Dolphins vs. Houston Texans | Sunday, December 15th, 2024 at 1:00pm ET |
| Week 16 | Houston Texans vs. Kansas City Chiefs | Saturday, December 21st, 2024 at 1:00pm ET |
| Week 17 | Baltimore Ravens vs. Houston Texans | Wednesday, December 25th, 2024 at 4:30pm ET |
| Week 18 | Houston Texans vs. Tennessee Titans | Sunday, January 5th, 2025 at 1:00pm ET |
