| Week 1 | Los Angeles Rams vs. Detroit Lions | Sunday, September 8th, 2024 at 8:20pm ET |
| Week 2 | Tampa Bay Buccaneers vs. Detroit Lions | Sunday, September 15th, 2024 at 1:00pm ET |
| Week 3 | Detroit Lions vs. Arizona Cardinals | Sunday, September 22nd, 2024 at 4:25pm ET |
| Week 4 | Seattle Seahawks vs. Detroit Lions | Monday, September 30th, 2024 at 8:15pm ET |
| Week 5 | Bye Week | |
| Week 6 | Detroit Lions vs. Dallas Cowboys | Sunday, October 13th, 2024 at 4:25pm ET |
| Week 7 | Detroit Lions vs. Minnesota Vikings | Sunday, October 20th, 2024 at 1:00pm ET |
| Week 8 | Tennessee Titans vs. Detroit Lions | Sunday, October 27th, 2024 at 1:00pm ET |
| Week 9 | Detroit Lions vs. Green Bay Packers | Sunday, November 3rd, 2024 at 4:25pm ET |
| Week 10 | Detroit Lions vs. Houston Texans | Sunday, November 10th, 2024 at 8:20pm ET |
| Week 11 | Jacksonville Jaguars vs. Detroit Lions | Sunday, November 17th, 2024 at 1:00pm ET |
| Week 12 | Detroit Lions vs. Indianapolis Colts | Sunday, November 24th, 2024 at 1:00pm ET |
| Week 13 | Chicago Bears vs. Detroit Lions | Thursday, November 28th, 2024 at 12:30pm ET |
| Week 14 | Green Bay Packers vs. Detroit Lions | Thursday, December 5th, 2024 at 8:15pm ET |
| Week 15 | Buffalo Bills vs. Detroit Lions | Sunday, December 15th, 2024 at 4:25pm ET |
| Week 16 | Detroit Lions vs. Chicago Bears | Sunday, December 22nd, 2024 at 1:00pm ET |
| Week 17 | Detroit Lions vs. San Francisco 49ers | Monday, December 30th, 2024 at 8:15pm ET |
| Week 18 | Minnesota Vikings vs. Detroit Lions | Sunday, January 5th, 2025 at 1:00pm ET |
