| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 20.3 | 20.7 | 25.2 | - | 13.8 | 34.8 | 23.5 | 6.7 | 20.7 | 145 | ||||||||||
| 2 | Josh Jacobs | RB | GB | 9.7 | 29.5 | 25.3 | - | 33.5 | 5.4 | 8.7 | 16.6 | 18.4 | 128.7 | ||||||||||
| 3 | Austin Ekeler | RB | WAS | 5.3 | 28.9 | 31.9 | 14.3 | 24.7 | - | 17.1 | 6.3 | 18.4 | 128.5 | ||||||||||
| 4 | Nick Chubb | RB | HOU | 17.3 | 18.7 | 25.4 | 7 | 16.7 | 24.4 | - | 12.1 | 17.4 | 121.6 | ||||||||||
| 5 | Saquon Barkley | RB | PHI | 18.6 | 16.2 | 16.6 | 15.5 | 13.5 | 12.2 | - | 22 | 16.4 | 114.6 | ||||||||||
| 6 | Dalvin Cook | RB | FA | 13.6 | 8.6 | 24.1 | 14.3 | - | 20.1 | 11.6 | 20.6 | 16.1 | 112.9 | ||||||||||
| 7 | Christian McCaffrey | RB | SF | 11.5 | 16.8 | 16.4 | 15.8 | 6.2 | 32.3 | BYE | 13.7 | 16.1 | 112.7 | ||||||||||
| 8 | Joe Mixon | RB | HOU | 3.8 | 13.4 | 8.8 | 12.8 | 15.1 | 5.9 | 51.1 | - | 15.8 | 110.9 |