| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 30.4 | 28.3 | 16.5 | 19.7 | 23.7 | 94.9 | ||||||||||||||
| 2 | Derrick Henry | RB | BAL | 31 | 34.6 | 15.4 | 6.8 | 22 | 87.8 | ||||||||||||||
| 3 | Alvin Kamara | RB | NO | 26.7 | BYE | 28.9 | 15.1 | 23.6 | 70.7 | ||||||||||||||
| 4 | Darrell Henderson Jr. | RB | FA | 16.4 | 23.7 | 7.9 | 21.8 | 17.5 | 69.8 | ||||||||||||||
| 5 | Joe Mixon | RB | HOU | 10 | 23.8 | 11.9 | 23.1 | 17.2 | 68.8 | ||||||||||||||
| 6 | Leonard Fournette | RB | FA | 19 | 27.7 | 16 | 5.8 | 17.1 | 68.5 | ||||||||||||||
| 7 | Damien Harris | RB | FA | 9.8 | 17.3 | 24.3 | 14 | 16.4 | 65.4 | ||||||||||||||
| 8 | D'Andre Swift | RB | CHI | 19.4 | 15.2 | 24.4 | 5.6 | 16.2 | 64.6 |