It would take something significant in the coming weeks for the top six in draft order to see changes in their average draft position (ADP), but down at the back end of round one, it could happen a little more easily. If Justin Jefferson and Kyler Murray have a positive camp, could Jefferson climb past this range? If James Cook is constantly catching passes, what does that mean for him? Those are questions we’ll get to in the coming weeks. For now, we can concentrate on how to approach the 1.10 in your fantasy football draft based on what we do know. Make sure to do a fantasy football mock draft or two to prep for your draft.
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Fantasy Football Draft Strategy: Pick 1.10
Players to Consider at 1.10 Fantasy Football Draft Pick
These players will likely be available when you make your selection:
The top of the draft will start with Bijan Robinson, Jahmyr Gibbs, and Ja’Marr Chase likely as the first three picks off the board. After that, it typically leans to Puka Nacua and Jaxon Smith-Njigba before things open up slightly. Amon-Ra St. Brown usually goes between the 1.06 and the 1.08, and in most leagues, you’ll see Jonathan Taylor and Christian McCaffrey going before you get a chance to take them. If either should fall, they’re easy picks, but if not, then these are the best targets.
Players to Target at 1.10 Fantasy Football Draft Pick
CeeDee Lamb (WR – DAL)
It was a really disappointing 2025 for CeeDee Lamb, posting the second-lowest numbers of his career in targets (117), receptions (75) and receiving yards (1,077), with only his rookie season in 2020 worse. He also had a career-low three touchdowns.
The newly arrived George Pickens recorded a 22.1% target share in the red zone compared to Lamb’s 18.6%, which was also behind Jake Ferguson, who led the team with 23.1%. Contrast this to 2024, when Lamb had a 27.7% red-zone target share and led the team by 10%. In 2023, it was 28.8% and also led the team by 10%.
If you’re happy to believe 2025 was a blip rather than the new normal, it becomes easier to see Lamb as a value pick in this range. Betting on Lamb’s well-established connection with Dak Prescott and this team as a whole to bounce back isn’t the worst bet in the world.
Justin Jefferson (WR – MIN)
Condolences if you rostered Justin Jefferson in 2025. According to our data, Jefferson teams had a 3.54% win rate in 2025. That level of return stings and isn’t something fantasy managers forget in a hurry, but there are reasons for optimism in 2026.
Jefferson is coming off career lows in receiving yards (1,084), receptions (68) and receiving touchdowns (two) in a season he played all games. This wasn’t Jefferson’s fault, however. Among wide receivers with 50+ targets, Jefferson ranked 58th in catchable target rate (71%).
J.J. McCarthy stunk, and all indications are that Kyler Murray is the clear favorite to be the starter in 2026, and possibly beyond. The Vikings had the fourth-fewest pass attempts per game under McCarthy. In 2024, under Sam Darnold, they ranked 17th. Given the lackluster running back room, Jefferson should be fine if his catchable target rate increases and he sees a bump in volume.
James Cook (RB – BUF)
In 2024, James Cook dominated, scoring 16 touchdowns and rushing for 1,009 yards. That production seemed unsustainable. In 2025, he recorded 1,621 rushing yards and 12 touchdowns, and gave us even more reason to be confident.
With the Bills’ offense under Joe Brady never finding a dominant receiver, Cook has had to stand up and lead the offense, and there’s no reason to think that can’t continue this season.
The Bears didn’t seem to be concerned about losing DJ Moore, and the Bills paid a price far higher than most expected for a 29-year-old wide receiver who has never had double-digit touchdowns, with a season over 1,000 yards just once in the last four years.
While the passing offense will be spread around, Cook remains the safest and strongest bet outside of Josh Allen. If Allen ever sees regression on his 41 rushing touchdowns over the last three years, Cook is ready and waiting to clean up.
Players to Avoid at 1.10 Fantasy Football Draft Pick
Brock Bowers (TE – LV) & Trey McBride (TE – ARI)
Whether you prefer Brock Bowers or Trey McBride doesn’t really matter. Neither should be drafted this high. Last season, McBride averaged 18.6 PPR points per game, and Bowers averaged 15.5 in 2024, the better season of his two years in the NFL.
Five running backs and five wide receivers averaged more than 18.5 points per game in 2024, and 11 managed the same achievement in 2025. It’s incredibly hard for tight ends to score as highly as the top wide receivers and running backs, and both elite tight ends still have issues to face.
McBride caught fire with positive touchdown regression while the Cardinals led the league in passing, and he ran 67 more routes than any tight end in at least 20 years.
Bowers, meanwhile, is onto his third quarterback in three years and will be hoping that Fernando Mendoza adjusts quickly to the NFL. There’s no sense in reaching for one of these players unless your league features a TE-Premium scoring setting. Only then can both be in the argument for first-round picks.
De’Von Achane (RB – MIA)
Last season, De’Von Achane exceeded his previous career-high 907 rushing yards by 443 rushing yards (1,350). He surpassed 1,000 rushing yards for the first time in his career while hitting 85+ targets for the second consecutive year.
It’s hard, though, not to be concerned that his numbers in the receiving game could dip significantly without Tua Tagovailoa, having averaged five targets per game with him and 2.45 without him. The offense has no weapons, and if they can’t move the ball and stay on the field, it could be catastrophic for Achane’s value.
Roster Constructions to Consider at 1.10 Fantasy Football Draft Pick
The back end of the draft board is a good place to double up on either running backs or wide receivers if you don’t want to go with the balanced approach. You can pair either James Cook and Saquon Barkley or CeeDee Lamb and Drake London, both of which are interesting starts.
Running back tends to dry up quicker than usual this year, but only having one wide receiver through three rounds can leave your wide receiver room struggling to catch up. It’s a good year to consider a more balanced approach.
Fantasy Football Mock Draft From the 1.10 Pick
We used our FREE fantasy football mock draft simulator to show you an example of a draft from the 1.10 position. You can sync your league for free and mock draft against your fantasy football league settings to prepare more specifically for your draft.
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