Week 10 brings us another large slate with plenty of fun matchups to target, even if the afternoon games look somewhat disappointing. As the season progresses and the better offenses become clearer, it can be easier to narrow down the pool we want for cash games (Double Ups/Multipliers); we can lean into the projectable volume and favorability of those matchups. These are the best plays for DFS cash games this week.

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NFL DFS Cash Game Lineup Advice & Picks (Week 10)

Brock Purdy (QB – SF) vs. TB | DraftKings: $6500 / FanDuel: $8100

The Niners return from their bye week, and much of the focus will be on the potential return of Christian McCaffrey, who hasn’t played a snap this year after dealing with an Achilles issue since the preseason. As much as McCaffrey deserves attention and likely will only increase in price, this game is better for the passing attack than the ground attack. The Bucs rank sixth in FTN’s Run Defense DVOA (Defense-Adjusted Value Over Average) metric, whereas they rank 18th against the pass. According to FantasyPoints.com, the Bucs play the most zone coverage in the league, a look that Brock Purdy ranks third against in yards per attempt, as well as averaging the seventh-most scramble yards against this coverage. Deebo Samuel and George Kittle both feast against the zone, and Purdy is coming off three consecutive top-12 performances to face a Bucs defense that’s allowed the third-most QB fantasy points this year with four top-3 finishes in their last five games.

QB Brock Purdy showed off those legs against Dallas???? #49ers #FTTB #BrockPurdy pic.twitter.com/6J3Ok8DMh5

— 49er_Edits (@49er_edits) November 7, 2024

Justin Herbert (QB – LAC)  vs. TEN | DraftKings: $5200 / FanDuel: $6900

The Justin Herbert Renaissance is underway and this price is straight-up disrespectful. Herbert started the season slow after dealing with a foot injury through preseason and during the opening four games, averaged a disappointing 22.7 passes per game, but since the Chargers bye week in Week 5, Herbert is averaging 33.0 passes per game and has finished as a top-12 quarterback in the last two weeks. At this cost, we’re looking for Herbert to get to around 18 points, depending on your platform, something he’s done in each of the last two starts.

Aaron Jones (RB – MIN) vs. JAX | DraftKings: $6700 / FanDuel: $7900

The Vikings have stumbled slightly in recent weeks, not looking quite as impressive as they did in the opening portion of the season, only scoring over 23 points once in the last four games, but this feels like the get-right spot they require. Aaron Jones has seen 46 touches in his last two games but failed to find the end zone, which has resulted in him finishing RB26 in consecutive weeks. The Jaguars are stronger against the run than the pass, but they’ve still allowed the eighth-highest explosive run rate (7.0%) and six different top-12 RB performances, including top-3 performances in each of the last two games they’ve played.

Alvin Kamara (RB – NO) vs. ATL | DraftKings: $8100 / FanDuel: $8500

Things aren’t going terribly well for the Saints this year, and their decision to extend Alvin Kamara looks more and more perplexing as each week creeps along, but the certainty about Kamara’s role at least allows us to feel good about how to approach him each week. After looking inefficient between Weeks 4-7, Kamara looked incredibly efficient in Weeks 8 and 9, averaging 6.0 yards per carry on 39 attempts, forcing nine missed tackles and breaking three big runs. It’s fair to consider that last week was against the woeful Panthers run defense, but Week 8 was against a sturdy Chargers team that gave up a season-high 18.2 points to Kamara. The Saints simply have very little else, and Kamara’s receiving floor of an average of 7.0 targets per game is as strong as any RB in the league. When the teams played in Week 4, Kamara finished with 24.9 PPR points on the back of 26 touches. Don’t be surprised if he ends up with more this week.

Alvin Kamara …

Career-high touches: 287
Current 2024 pace: 370

— Ian Hartitz (@Ihartitz) November 4, 2024

D’Andre Swift (RB – CHI) vs. NE | DraftKings: $6500 / FanDuel: $7700

The Patriots run defense allows the seventh-most yards per game (136.9) has given up the eighth-most rushing touchdowns (10) and surrenders the third-highest rate of yards after contact per attempt (2.61) per FantasyPoints.com. New England has also allowed six different running backs to total over 25 receiving yards against them, which is an area D’Andre Swift can exploit too. Swift has the tenth-most RB targets (29) and the fifth-highest yards per target among RBs (7.72). One of the few things that has been working for them involves D’Andre Swift, and before last week’s collapse against Arizona, Swift had enjoyed a run of four straight top-12 weekly finishes.

Deebo Samuel (WR – SF) vs. TB | DraftKings: $6900 / FanDuel: $8300

Tampa Bay leads the league in zone coverage rates, the type of coverage that Deebo Samuel has historically crushed, and while it hasn’t been pretty so far this year for Samuel, coming out of the bye week, he should be healthier and ready to put up a strong performance. Samuel has scored over 18 PPR points in half of his games this year and will be taking on a defense that’s allowed six top-10 weekly finishes to receivers, including in each of the last three weeks. With Brandon Aiyuk out for the year, this should be the start of another great season for Samuel.

Drake London (WR – ATL) vs. NO | DraftKings: $6700 / FanDuel: $7800

After leaving last week’s game shortly after scoring a touchdown, fantasy managers were given a scare, but thankfully, Drake London sounds to be on track to play in Week 10, and one of the breakout talents of the season can continue to deliver. The Saints traded their best cornerback (Marshon Lattimore) shortly after firing their head coach, Dennis Allen, leaving a bad defense to get even worse. The Saints have allowed the 10th most WR fantasy points this year and last time the teams met in Week 4 Drake London saw 12 targets. London has scored touchdowns in all but three games this year and has over 60 yards in five of these nine. Darnell Mooney has been flashing of late but he feels like a better GPP play than Cash game solution.

Drake London on his hip pointer: "I feel mentally great. It's just a day-by-day thing and I just gotta keep on working with the PT staff and the training staff and with the coaches, and if they're willing to let me play, then I'm gonna be out there. #Falcons

— Marc Raimondi (@marcraimondi) November 7, 2024

Ladd McConkey (WR – LAC) vs. TEN | DraftKings: $5900 / FanDuel: $6300

In cash games, sometimes volume can be all that you need, and that’s been something that hasn’t been hard to come by for Ladd McConkey. The former Georgia rookie averages 6.5 targets per game, second only to Malik Nabers‘s 12.0 among rookies. McConkey has been averaging an 87% route participation since the week 5 bye and should be in for a strong week against a Titans team that allows a league-leading 0.26 targets per route run to slot receivers along with the eighth-highest catch rate. McConkey lacks the ceiling we’d want in GPP’s, but in cash, he should see enough work to pay off his salary.

DeMario Douglas (WR – NE) vs. CHI | DraftKings: $4400 / FanDuel: $5100

It wasn’t too long ago that DeMario Douglas was hot property in the fantasy streets, but then he spent most of the Patriots game in London dealing with illness, and all of a sudden, nobody wanted to play him. In Week 9, Douglas had nine targets and caught seven of them. Douglas managed little with these targets, gaining 35 yards on them, but in points-per-reception formats, we can live with that. Ja’Lynn Polk hasn’t emerged, and Kj Osborn was a healthy scratch in Week 9, leaving the runway clear for Douglas to continue to be a PPR scam.

Taysom Hill (TE/QB – NO) vs. ATL | DraftKings: $4000 / FanDuel: $6300

With the Saints increasingly beaten up, it was no surprise to see season-high usage for Taysom Hill, who saw nine touches for 60 yards and a touchdown in Week 9 and also had a season-high 47% route participation. Hill had five targets and five rush attempts, resulting in 16.0 PPR points, and with Chris Olave set to miss at the very least Week 10, don’t be surprised if the game plan for the Falcons involves a healthy amount of Hill once again.

Taysom Hill has only played in four full games this year.

He's been a top-5 PPR fantasy TE in two of those four games.

— Dave Kluge (@DaveKluge) November 4, 2024

Will Dissly (TE – LAC) vs. TEN | DraftKings: $3100 / FanDuel: $4900

Three Chargers players in one article might be a bit much for some people, and it’s not necessarily a suggestion to play all three of them in one lineup, but it speaks to the fact that the Chargers are second in pass rate over expected in the last month and Justin Herbert looks to be getting better and better. Will Dissly is coming off a season-low nine yards on two receptions after managing 122 yards in the previous two games combined. There’s always a risk when we punt the tight end position, but at $3100, it allows us to find much greater points scores elsewhere in our lineup.

FanDuel Only

Tank Dell (WR – HOU) vs. DET | FanDuel $7200

With the extended slate that FanDuel offers, including Sunday Night Football, it gives us access to The Texans taking on the Lions and likely another week of Tank Dell seeing plenty of volume. Dell has scored over 13 PPR points in back-to-back games with his first 100-yard game of the season coming in Week 9. The Lions allow the third-most WR fantasy points and come into this game on the back of allowing 16.3 points to Jayden Reed (WR23), the week after giving up 22.6 to Calvin Ridley (WR5), which was the week after they gave up 21.4 to Justin Jefferson (WR5). If Nico Collins misses out again, it’s wheels up on the Tank for at least one more week.

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