Dynasty Rookie Draft Advice: Isaac Guerendo (2024 Fantasy Football)

This is what we’ve been waiting for, fantasy football enthusiasts. The NFL Draft is under way, and we finally get to see where the rookie prospects are going to launch their professional careers. And NFL Draft landing spots allow us to start to zero in on fantasy football and dynasty rookie draft pick values.

Throughout the draft, we’ll take a closer look at fantasy-relevant prospects, giving you an overview of their strengths and weaknesses, and assessing their fantasy value in both redraft and dynasty formats.

Let’s dig in.

Fantasy Football Rookie Draft Outlook

Fitz’s Fantasy Football Outlook

The San Francisco 49ers have selected RB Isaac Guerendo of Louisville with the 29th pick of the fourth round.

Guerendo grabbed the attention of fantasy managers and hardcore football fans when he clocked a 4.33 at the NFL Scouting Combine at 6-0, 221 pounds. A remarkable athletic specimen, Guerendo posted a Relative Athletic Score of 9.97, one of the five best RAS numbers recorded by a running back since 1987.

As amazing as Guerendo’s testing numbers are, his college resume is light. He spent four years at Wisconsin, where he was buried on the depth chart, first behind Jonathan Taylor, then behind Braelon Allen. He spent his final college season at Louisville, where he shared work and had 132 carries for 810 yards and 11 touchdowns, along with 22 catches for 234 yards.

Unfortunately, there doesn’t appear to be much of a path to fantasy relevance for Guerendo in his rookie year, with Christian McCaffrey entrenched as the 49ers’ do-everything lead back and Elijah Mitchell as CMC’s backup. But Guerendo is still an intriguing longer-term play in dynasty leagues.

I have Guerendo ranked RB13 among rookies, with an overall dynasty ranking of RB67.

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Thor’s NFL Draft Profile & Player Comp

6000/221 | RAS: 9.97
Player Comparison: C.J. Prosise

Size/speed freak who flashed some receiving chops in 2023. Never more than a complimentary platoon guy at Wisconsin and then Louisville. Though he also had great agility showings at the NFL Combine, Isaac Guerendo’s tape shows a north/south athlete looking for a runway to the end zone to sprint straight down when he gets the ball. I’d like to see more creativity with the ball in his hands to play up his natural athleticism. Intriguing sleeper with plenty of tread on his tires.

Check out more NFL Draft profiles and player comps from Thor in our 2024 NFL Draft Guide