This week we have the Bills and Chiefs as our main matchup, which should be a good one. The Bills have made significant upgrades to their defensive line in recent years, and they are starting to see those moves pay off. How much they can get to Patrick Mahomes will be a big key to the game.

Let’s take a look at three Week 6 matchups.

Check out all of our Week 6 fantasy football content

Matchup of the Week

Buffalo Bills DL (3rd in FantasyPros OL Rankings) @ Kansas City Chiefs OL (9th in FantasyPros DL Rankings)

This is the marquee matchup of Week 6 in the NFL. The Bills have pointed to this game since last January, and their off-season addition of Von Miller was made for this type of matchup. Patrick Mahomes is one of the best improvisers in all of football, so the Bills have a big task ahead, and their defensive line is one of the keys to the game. This is a strength-on-strength matchup with Buffalo ranking 6th in pass defense DVOA and 1st in yards allowed per pass, while Kansas City is 4th in pass offense DVOA and yards per pass.