Check out our top waiver wire targets for Week 6 of the 2022 fantasy football season. Here are defenses you should target when making your Week 6 waiver wire bids.

• Fantasy Football Week 6 Waiver Wire FAAB Advice
• Erickson’s Week 5 Rapid Reactions & Top Performers
• Fantasy Football Panic Meter
• Fantasy Football Week 5 Takeaways: Surprises & Disappointments
• Fantasy Football Heat Index
• Fantasy Football Rest of Season Rankings

If you want to dive deeper into fantasy football, be sure to check out our award-winning slate of Fantasy Football Tools as you navigate your season. From our Start/Sit Assistant – which provides your optimal lineup, based on accurate consensus projections – to our Waiver Wire Assistant – which allows you to quickly see which available players will improve your team, and by how much – we’ve got you covered this fantasy football season.

Fantasy Football Waiver Wire Targets: Defenses

New England Patriots: 41% rostered

• Next opponents: @CLE, CHI, @NYJ
• True value: $1
• Desperate need: $2
• Budget-minded: $1

Analysis: Fresh off a shutout of the previously high-flying Lions offense, the Patriots visit Cleveland. It’s not easy for a defense to score points against a run-heavy team like the Browns, but Bill Belichick’s defenses always seem to find a way to provide fantasy value. Matchups against the Bears in Week 7 and the Jets in Week 8 give New England multi-week viability.

Indianapolis Colts: 33% rostered

• Next opponents: JAC, @TEN, WAS
• True value: $1
• Desperate need: $2
• Budget-minded: $0

Analysis: The Colts’ offense may be broken, but their defense is legit. The entered Week 5 ranked 13th in defensive DVOA and second in DVOA against the run. The Jaguars pay a visit to Indianapolis seven days after their offense malfunctioned in a loss to the Texans. That game might have been a one-week hiccup for the Jags’ offense, but this is still a neutral matchup at worst for the Indy defense. The Colts also get playable matchups against the Titans, Commanders and Patriots in Weeks 7-9.

Cincinnati Bengals: 28% rostered

• Next opponents:@NO, ATL, @CLE
• True value: $1
• Desperate need: $2
• Budget-minded: $0

Analysis: The Cincinnati D was averaging a respectable 7.5 fantasy points per game entering Week 5 and gets a playable Week 5 matchup against the Saints, who’ll be quarterbacked by either Jameis Winston or Andy Dalton. You could potentially use the Bengals against the Falcons in Week 7 and the Browns in Week 8 as well..

Cleveland Browns: 15% rostered

• Next opponents: NE, @BAL, CIN
• True value: $1
• Desperate need: $2
• Budget-minded: $0

Analysis: With only nine sacks and two interceptions on the season, the Browns’ defense has amassed few fantasy points in 2022. But edge rusher Myles Garrett returned to action last week after recovering from a rollover car crash, and CB Greedy Williams could make his season debut after missing the first five games with a hamstring injury. The Browns host the Patriots, who’ll be quarterbacked by either Mac Jones two weeks after a high-ankle sprain, venerable journeyman Brian Hoyer or third-string rookie Bailey Zappe. The Browns would be a one-week rental only. You wouldn’t want to use them against the Ravens in Week 7.