We compiled several projection sources to come up with consensus projections. We then compared these projections to the prop bet odds from DraftKings Sportsbook to give you the best prop bet picks. Here are our top 10 picks for Week 10.

View the best NFL prop bets for Week 10 with our Prop Bet Cheat Sheet

D.J. Moore (WR – CAR): OVER 54.5 Receiving Yards
D.J. Moore has been a huge disappointment for fantasy owners over the last two weeks, as he has totaled four catches for 73 yards on nine total targets. Now that he is facing a Buccaneers defense who has allowed the 23rd most points to opposing fantasy wide receivers, it is easy to think he is in for another quiet day. However, with Christian McCaffrey out of the lineup, Moore has had 55+ receiving yards five times. In a game where they are expected to be trailing, Moore should be the beneficiary of an uptick in targets. Moore has gained 40+ yards on 2 of his 13 receptions since Week 6 (2nd-most among 72 qualified receivers), so he does not need a lot of volume to rack up big yardage totals.

Leonard Fournette (RB – TB): OVER 47.5 Rushing Yards
Slowly but surely, Leonard Fournette is working his way into the featured back role in this Tampa Bay offense. Throw out all last week’s data as the Buccaneers attempted an NFL-record low five rushing attempts for the game. Before that on Monday night, Ronald Jones was clearly benched after a fumble set up the Giants deep in their own territory. Fournette went on to handle 15 carries in that game and has double-digit carries in three of his last five games. In a game that they are projected to be leading in the fourth quarter, the more sure-handed Fournette should be called on to grind out the game-winning yards.

Miles Sanders (RB – PHI): OVER 54.5 Rushing Yards
Miles Sanders has missed the last two games with a knee injury but appears fully healthy following Philadelphia’s bye week. He faces a Giants defense that ranks 15th in fantasy points allowed to opposing running backs. Considering Sanders averaged 99 rushing yards per game in the last two games he was healthy against two of the best run defenses in the Steelers and Ravens, Sanders figures to be a sure bet to exceed this 54.5 yard total even if he has to share some of the workload with Boston Scott.

Jalen Reagor (WR – PHI): OVER 37.5 Receiving Yards
Jalen Reagor has averaged 37.3 receiving yards per game in the three games he has been healthy, so this projection is right on that season average. However, Reagor should benefit from the healthiest complement of teammates at the skill positions that he has had all year. With Alshon Jeffery potentially being shadowed by the tremendous cornerback James Bradberry and more loaded boxes to stop Miles Sanders, Reagor should have more one-on-one opportunities to exploit.  

Chris Godwin (WR – TB): OVER 52.5 Receiving Yards
Chris Godwin has averaged 64.0 YPG in the five games he has been healthy this year. Last week was the first game he played since being out with a broken finger, and he still was targeted six times. Quarterback Tom Brady still clearly has trust in his playmaker, as is evident by his 25 targets inside the 10-yard line since 2018 (most among any WRs). Since 2017 when Godwin is below his average number of six targets, his team is just 9-20. In a game the Buccaneers absolutely have to win to keep pace with the Saints, it would behoove head coach Bruce Arians to get Godwin involved early and often.

Miles Sanders (RB – PHI): OVER 17.5 Receiving Yards
A Giants defense that ranks 25th against the pass will face an Eagles offense that is nothing like the one they faced three weeks ago. With Alshon Jeffery and Jalen Reagor now available, New York’s linebackers and secondary will have to respect their big-play ability, which should lead to plenty of opportunities underneath for Miles Sanders. Sanders has averaged 9.7 yards per reception since the 2019 season, which ranks fourth among 33 qualified running backs. Head coach Doug Pederson will be excited to have one of his best playmakers healthy for the first time in three weeks, and he should be afforded many opportunities both running and receiving.

Travis Fulgham (WR – PHI): OVER 61.5 Receiving Yards
We have talked at length about how Philadelphia’s skill position players will benefit as a whole now that more people are healthy, and that certainly applies to Travis Fulgham. Fulgham has been a top-15 fantasy receiver in three of his last four games. He had five catches for 73 yards in these teams’ first meeting three weeks ago, and that was despite getting shadowed by New York’s best cornerback James Bradberry for most of the game. Fulgham has totaled 73+ yards in four of the five games he has played in this season, so there is no reason to think he will not exceed a much lower projected total against the Giants’ 25th-ranked pass defense. 

Evan Engram (TE – NYG): OVER 37.5 Receiving Yards
Slowly but surely, Evan Engram is becoming a more involved player in the Giants offense each week. He has been targeted 32 times since Week 6, which is second-most among tight ends and his 18 receptions and 185 receiving yards in that span are the fourth-most league-wide at the position. Engram had 46 receiving yards three weeks ago against the Eagles, and there is nothing about his involvement in the offense since then to suggest he cannot turn in similar production this week.

Daniel Jones (QB – NYG): UNDER 234.5 Passing Yards
When the opposing team’s uniform does not have Washington written on it, Daniel Jones is not the same quarterback. He has lost 16 straight starts against teams not named Washington, largely because of a league-leading 36 turnovers since the start of last season. He threw for just 187 yards against this Eagles defense three weeks ago as he was under constant pressure. In fact, Jones has been pressured on 28% of his pass attempts since the 2019 season, which is tied for the highest percentage among 27 qualified quarterbacks. Look for head coach Joe Judge to implement a conservative game plan so as to keep Jones upright, but one that will lead to fewer pass attempts.

Mike Evans (WR – TB): OVER 51.5 Receiving Yards
We are all in on the Buccaneers skill position players this week, as Tom Brady should rebound nicely after a 5.36 point fantasy performance last week against the Saints. Mike Evans had one of his best games of the season in Week 2 against the Panthers when he totaled 104 yards and a touchdown on ten targets. Evans’ yardage totals have improved in four straight games which is a sign he is getting more in sync with Brady than simply being just a red-zone target. Evans has averaged 11.3 FPPG since the 2019 season and should be able to feast once again on this Carolina secondary.

Check out our Prop Bet Cheat Sheet for the top bets of the week

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Mike Spector is a featured writer at BettingPros. For more from Mike, check out his archive and follow him @MikeSpector01.